| Entry |
|
|---|
| Name |
Trimethoprim hydrochloride;
Primsol (TN);
Trimpex (TN) |
|---|
| Formula |
C14H18N4O3. HCl
|
|---|
| Exact mass |
326.1146
|
|---|
| Mol weight |
326.7787
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antibacterial
DG01581 Trimethoprim antibacterial
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
|
|---|
| Remark |
| Product (DG00595): | D00145<US> |
| Product (mixture): | D11086<US> |
|
|---|
| Efficacy |
Antibacterial, Folic acid biosynthesis inhibitor |
|---|
| Disease |
Uncomplicated urinary tract infections [DS: H01176] |
|---|
| Target |
dihydrofolate reductase [KO: K13938] |
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP2C8 [HSA: 1558]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01E SULFONAMIDES AND TRIMETHOPRIM
J01EA Trimethoprim and derivatives
J01EA01 Trimethoprim
D11085 Trimethoprim hydrochloride
Drug groups [BR:br08330]
Antibacterial
DG01581 Trimethoprim antibacterial
DG00595 Trimethoprim
D11085 Trimethoprim hydrochloride
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG00595 Trimethoprim
D11085 Trimethoprim hydrochloride
Antimicrobials [BR:br08307]
Antibacterials
Folic acid biosynthesis inhibitor
Trimethoprim
D11085 Trimethoprim hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11085
Drug groups [BR:br08330]
Antibacterial
DG01581 Trimethoprim antibacterial
DG00595 Trimethoprim
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG00595 Trimethoprim
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Folic acid biosynthesis inhibitor
Trimethoprim
DG00595 Trimethoprim
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 22
1 C8y C 18.0338 -17.1983
2 C1b C 19.2174 -17.8945
3 C8x C 16.8501 -17.8945
4 C8x C 18.0338 -15.8057
5 C8y C 20.4011 -17.1983
6 C8y C 15.5968 -17.1983
7 C8y C 16.8501 -15.1094
8 C8y C 21.6544 -17.8945
9 C8x C 20.4011 -15.7361
10 C8y C 15.5968 -15.8057
11 O2a O 14.4132 -17.8945
12 O2a O 16.8501 -13.7169
13 N5x N 22.8381 -17.1983
14 N1a N 21.6544 -19.2871
15 N5x N 21.6544 -15.0398
16 O2a O 14.4132 -15.1791
17 C1a C 13.2295 -17.1286
18 C1a C 18.0338 -13.0206
19 C8y C 22.8381 -15.7361
20 C1a C 14.4132 -13.7169
21 N1a N 24.0217 -15.0398
22 X Cl 26.2500 -19.1800
BOND 22
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 3 6 2
6 4 7 1
7 5 8 2
8 5 9 1
9 6 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 8 14 1
14 9 15 2
15 10 16 1
16 11 17 1
17 12 18 1
18 13 19 2
19 16 20 1
20 19 21 1
21 7 10 2
22 15 19 1
|
|---|
