KEGG   DRUG: Tapinarof
Entry
D11365                      Drug                                   
Name
Tapinarof (JAN/USAN);
Vtama (TN)
Product
VTAMA (Dermavant Sciences)
Formula
C17H18O2
Exact mass
254.1307
Mol weight
254.3236
Structure
Simcomp
Remark
ATC code: D05AX07
Product: D11365<US>
Efficacy
Anti-inflammatory, Aryl hydrocarbon receptor agonist
  Disease
Plaque psoriasis [DS:H01656]
Comment
Treatment of atopic dermatitis and psoriasis
Target
AHR [HSA:196] [KO:K09093]
  Pathway
hsa04659  Th17 cell differentiation
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D05 ANTIPSORIATICS
   D05A ANTIPSORIATICS FOR TOPICAL USE
    D05AX Other antipsoriatics for topical use
     D05AX07 Tapinarof
      D11365  Tapinarof (JAN/USAN) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatological Agents, Other
   Psoriasis Agents
    Tapinarof
     D11365  Tapinarof (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Signaling molecules
   Transcription factor
    AHR
     D11365  Tapinarof (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11365
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11365
Other DBs
CAS: 79338-84-4
PubChem: 384585343
ChEBI: 215747
LinkDB
KCF data

ATOM        19
            1   C8x C     8.5400  -17.9200
            2   C8x C     8.5400  -19.3200
            3   C8x C     9.7524  -20.0200
            4   C8x C    10.9649  -19.3200
            5   C8y C    10.9649  -17.9200
            6   C8x C     9.7524  -17.2200
            7   C2b C    12.1960  -17.2090
            8   C2b C    13.4012  -17.9047
            9   C8y C    14.5835  -17.2219
            10  C8x C    15.7775  -17.9112
            11  C8y C    16.9899  -17.2112
            12  C8y C    16.9899  -15.8112
            13  C8y C    15.7960  -15.1219
            14  C8x C    14.5835  -15.8219
            15  O1a O    15.7959  -13.7202
            16  O1a O    18.2212  -17.9222
            17  C1c C    18.2134  -15.1046
            18  C1a C    19.4224  -15.8025
            19  C1a C    18.2132  -13.7201
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   13  15 1
            17   11  16 1
            18   12  17 1
            19   17  18 1
            20   17  19 1

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