KEGG   DRUG: Dutasteride and tamsulosin
Entry
D11389            Mixture   Drug                                   
Name
Dutasteride and tamsulosin;
Jalyn (TN)
Product
  Generic
DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE (AvKARE), DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE (Par Pharmaceutical), DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE (Zydus Lifesciences Limited), DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE (Zydus Pharmaceuticals USA)
Component
Dutasteride [DR:D03820], (Tamsulosin hydrochloride [DR:D01024] | Tamsulosin [DR:D08560])
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
ATC code: G04CA52
Product: D11389<US>
Efficacy
Prostatic hyperplasia treatment
Comment
Dutasteride is metabolized by the CYP3A4 and CYP3A5.
Tamsulosin is metabolized by the CYP3A4 and CYP2D6.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA52 Tamsulosin and dutasteride
      D11389  Dutasteride and tamsulosin <US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Dutasteride/ Tamsulosin Hydrochloride
    D11389  Dutasteride and tamsulosin
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D11389  Dutasteride and tamsulosin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11389  Dutasteride and tamsulosin
  DG02925  CYP3A5 substrate
   D11389  Dutasteride and tamsulosin
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11389
Other DBs
PubChem: 384585367
LinkDB

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