KEGG   DRUG: Sodium levofolinate
Entry
D11394                      Drug                                   
Name
Sodium levofolinate;
Levoleucovorin disodium;
Khapzory (TN)
Product
KHAPZORY (Acrotech Biopharma)
Formula
C20H21N7O7. 2Na
Exact mass
517.1298
Mol weight
517.403
Structure
Simcomp
Remark
ATC code: V03AF10
Chemical structure group: DG03003
Product (DG03003): D04715<US> D11394<US> D11555<JP/US>
Efficacy
Antidote (antifolate), Antineoplastic (enhancer)
  Disease
Osteosarcoma [DS:H00036]
Colorectal cancer [DS:H00020]
Comment
Levoleucovorin counteracts the therapeutic and toxic effects of folic acid antagonists
Levoleucovorin enhances the therapeutic and toxic effects of fluorouracil
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AF Detoxifying agents for antineoplastic treatment
     V03AF10 Sodium levofolinate
      D11394  Sodium levofolinate <US>
Other DBs
CAS: 1141892-29-6
PubChem: 384585372
LinkDB
KCF data

ATOM        36
            1   C1c C    24.1808  -14.7732
            2   C1b C    25.3655  -15.4701
            3   C6a C    24.1808  -13.3796
            4   C8y C     9.6867  -19.0239
            5   N5x N     9.6867  -17.5606
            6   C8y C    10.8713  -16.8638
            7   C8y C    12.0559  -17.5606
            8   C8y C    12.0559  -19.0239
            9   N4x N    10.8713  -19.7208
            10  N1y N    13.3102  -16.8638
            11  C1y C    14.4948  -17.5606
            12  C1x C    14.4948  -19.0239
            13  N1x N    13.3102  -19.7208
            14  O5x O    10.8713  -15.4701
            15  C4a C    13.3102  -15.4701
            16  O4a O    14.4948  -14.7732
            17  N1a N     8.4324  -19.7208
            18  C1b C    15.6794  -16.8638
            19  N1b N    16.8641  -17.5606
            20  C8y C    18.0487  -16.8638
            21  C8x C    18.0487  -15.4701
            22  C8x C    19.3727  -14.7732
            23  C8y C    20.5573  -15.4701
            24  C8x C    20.5573  -16.8638
            25  C8x C    19.3727  -17.5606
            26  C5a C    21.8116  -14.7732
            27  N1b N    22.9962  -15.4701
            28  O5a O    21.8116  -13.3796
            29  O6a O    25.3655  -12.6827 #-
            30  O6a O    22.9265  -12.6827
            31  C1b C    26.5501  -14.7732
            32  C6a C    27.7347  -15.4701
            33  O6a O    28.9193  -14.7732 #-
            34  O6a O    27.7347  -16.8638
            35  Z   Na   28.4900  -13.2300 #+
            36  Z   Na   26.8800  -11.6200 #+
BOND        36
            1     1   2 1
            2     1   3 1 #Down
            3     4   5 2
            4     5   6 1
            5     6   7 1
            6     7   8 2
            7     8   9 1
            8     4   9 1
            9     7  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    8  13 1
            14    6  14 2
            15   10  15 1
            16   15  16 2
            17    4  17 1
            18   11  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   24  25 2
            26   20  25 1
            27   23  26 1
            28   26  27 1
            29   26  28 2
            30    1  27 1
            31    3  29 1
            32    3  30 2
            33    2  31 1
            34   31  32 1
            35   32  33 1
            36   32  34 2

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