KEGG   DRUG: Leronlimab
Entry
D11399                      Drug                                   
Name
Leronlimab (USAN/INN)
Formula
C6534H10036N1720O2040S42
Exact mass
146580.2721
Mol weight
146670.6296
Sequence
(Heavy chain)
EVQLVESGGG LVKPGGSLRL SCAASGYTFS NYWIGWVRQA PGKGLEWIGD IYPGGNYIRN
NEKFKDKTTL SADTSKNTAY LQMNSLKTED TAVYYCGSSF GSNYVFAWFT YWGQGTLVTV
SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV ESKYGPPCPS CPAPEFLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY VDGVEVHNAK TKPREEQFNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK AKGQPREPQV YTLPPSQEEM
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS RLTVDKSRWQ
EGNVFSCSVM HEALHNHYTQ KSLSLSLGK
(Light chain)
DIVMTQSPLS LPVTPGEPAS ISCRSSQRLL SSYGHTYLHW YLQKPGQSPQ LLIYEVSNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCSQSTHVP LTFGQGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H-136-L219, H149-H205, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'96, H'136-L'219, H'149-H'205, H'263-H'323, H'369-H'427, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Efficacy
Antiviral, Anti-CCR5 antibody
  Type
Monoclonal antibody
Comment
Treatment of HIV infection
Target
CCR5 (CD195) [HSA:1234] [KO:K04180]
  Pathway
hsa03250  Viral life cycle - HIV-1
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Chemokine receptors
    CCR5 (CD195)
     D11399  Leronlimab (USAN/INN)
Antimicrobials [BR:br08307]
 Antivirals
  Entry, fusion or uncoating inhibitor
   CCR5 antagonist
    D11399  Leronlimab (USAN/INN)
Other DBs
CAS: 674782-26-4
PubChem: 384585377
LinkDB

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