KEGG   DRUG: Lonapegsomatropin
Entry
D11486                      Drug                                   
Name
Lonapegsomatropin (USAN/INN);
Lonapegsomatropin-tcgd;
Skytrofa (TN)
Product
SKYTROFA (Ascendis Pharma Endocrinology)
Sequence
FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV
QCRSVEGSCG F
(Disulfide bridge: 53-165, 182-189)
  Type
Peptide
Class
Hormonal agent
 DG03170  Growth hormone receptor agonist
Remark
ATC code: H01AC09
Product: D11486<US>
Efficacy
Growth hormone (GH) receptor agonist
  Disease
Growth hormone deficiency [DS:H00254]
Comment
Treatment of growth hormone deficiency
Target
GHR [HSA:2690] [KO:K05080]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04935  Growth hormone synthesis, secretion and action
  Network
nt06324  GHRH-GH-IGF signaling
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AC Somatropin and somatropin agonists
     H01AC09 Lonapegsomatropin
      D11486  Lonapegsomatropin (USAN/INN) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Pituitary)
  Lonapegsomatropin
   D11486  Lonapegsomatropin (USAN/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG03170  Growth hormone receptor agonist
   D11486  Lonapegsomatropin
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    GHR
     D11486  Lonapegsomatropin (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11486
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11486
Other DBs
CAS: 1934255-39-6
PubChem: 384585462
LinkDB

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