| Entry |
|
|---|
| Name |
Ezetimibe and rosuvastatin;
Roszet (TN);
Rosuzet (TN) |
|---|
| Component |
|
|---|
| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
Metabolizing enzyme substrate
DG02924 UGT substrate
Transporter substrate
DG01913 ABCG2 substrate
DG02856 SLCO1B1 substrate
|
|---|
| Remark |
| Therapeutic category: | 2189 |
|
|---|
| Efficacy |
Antihyperlipidemic |
|---|
| Disease |
Hyperlipidemia [DS: H01635] Homozygous familial hypercholesterolemia [DS: H00155] |
|---|
| Comment |
Ezetimibe is metabolized by UDP-glucuronosyltransferase (UGT).
Rosuvastatin is a substrate for OATP1B1 and BCRP.
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, Other
Ezetimibe/ Rosuvastatin Calcium
D11520 Ezetimibe and rosuvastatin
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
218 Hyperlipidemia agents
2189 Others
D11520 Ezetimibe and rosuvastatin
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
D11520 Ezetimibe and rosuvastatin
Metabolizing enzyme substrate
DG02924 UGT substrate
D11520 Ezetimibe and rosuvastatin
Transporter substrate
DG01913 ABCG2 substrate
D11520 Ezetimibe and rosuvastatin
DG02856 SLCO1B1 substrate
D11520 Ezetimibe and rosuvastatin
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D11520 Ezetimibe and rosuvastatin
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11520
Drug transporters
D11520
|
|---|
| Other DBs |
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| LinkDB |
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