KEGG   DRUG: Lidocaine and tetracaine
Entry
D11553            Mixture   Drug                                   
Name
Lidocaine and tetracaine;
Pliaglis (TN);
Synera (TN)
Product
PLIAGLIS (Oba Pharmaceuticals), PLIAGLIS (Taro Pharmaceuticals U.S.A.)
  Generic
LIDOCAINE AND TETRACAINE (Innovida Pharmaceutique Corporation)
Component
Lidocaine [DR:D00358], Tetracaine [DR:D00551]
Class
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Product: D11553<US>
Efficacy
Analgesic (local, topical)
Comment
Lidocaine is metabolized by CYP1A2 with some contribution from CYP3A4.
Metabolism
Enzyme: CYP1A2 [HSA:1544]; CYP3A4 [HSA:1576]
Interaction
Brite
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine/ Tetracaine
    D11553  Lidocaine and tetracaine
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   D11553  Lidocaine and tetracaine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11553  Lidocaine and tetracaine
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11553
Other DBs
CAS: 444093-81-6
PubChem: 384585529
LinkDB

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