KEGG   DRUG: Phentermine and topiramate
Entry
D11710            Mixture   Drug                                   
Name
Phentermine and topiramate;
Qsymia (TN)
Product
Component
(Phentermine hydrochloride [DR:D05459] | Phentermine [DR:D05458]), Topiramate [DR:D00537]
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: A08AA51
Product: D11710<US>
Efficacy
Antiobesity
Comment
Phentermine is metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA51 Phentermine and topiramate
      D11710  Phentermine and topiramate <US>
USP drug classification [BR:br08302]
 Anti-Obesity Agents
  Phentermine Hydrochloride/ Topiramate
   D11710  Phentermine and topiramate
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11710  Phentermine and topiramate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11710
Other DBs
CAS: 960078-81-3
PubChem: 405226576
LinkDB

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