KEGG   DRUG: Futibatinib
Entry
D11725                      Drug                                   
Name
Futibatinib (JAN/USAN/INN);
Lytgobi (TN)
Product
LYTGOBI (TAIHO PHARMACEUTICAL)
Formula
C22H22N6O3
Exact mass
418.1753
Mol weight
418.4485
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03208  FGFR inhibitor
Remark
Therapeutic category: 4291
ATC code: L01EN04
Product: D11725<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Cholangiocarcinoma (FGFR2 gene fusion) [DS:H00046]
Comment
Treatment of advanced solid tumors
Target
FGFR2* (CD332) [HSA_VAR:2263v2] [HSA:2263] [KO:K05093]
  Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04010  MAPK signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EN Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors
     L01EN04 Futibatinib
      D11725  Futibatinib (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Futibatinib
    D11725  Futibatinib (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D11725  Futibatinib (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03208  FGFR inhibitor
     D11725  Futibatinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR2* (CD332) [HSA_VAR:2263v2]
     D11725  Futibatinib (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11725
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11725
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11725
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11725
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D11725
Other DBs
CAS: 1448169-71-8
PubChem: 405226591
PDB-CCD: TZ0[PDBj]
LinkDB
KCF data

ATOM        31
            1   C8y C    37.6672  -21.3804
            2   C8x C    36.4833  -20.7368
            3   C8y C    35.3084  -21.3950
            4   C8x C    35.2549  -22.8133
            5   C8y C    36.3805  -23.4957
            6   C8x C    37.6253  -22.8376
            7   C3b C    34.0742  -20.6542
            8   C3b C    32.9099  -19.9135
            9   C8y C    31.7457  -19.1727
            10  N5x N    31.7992  -17.7543
            11  N4y N    30.4789  -17.2854
            12  C8y C    29.5323  -18.3716
            13  C8y C    30.3655  -19.5002
            14  N5x N    28.1330  -18.5436
            15  C8x C    27.5282  -19.7858
            16  N5x N    28.3613  -20.9145
            17  C8y C    29.7410  -20.8396
            18  N1a N    30.5158  -22.0069
            19  O2a O    36.3699  -24.8944
            20  C1a C    37.5225  -25.5964
            21  O2a O    38.9121  -20.7224
            22  C1a C    40.1346  -21.4244
            23  C1y C    30.0230  -15.9439
            24  C1x C    30.8996  -14.8577
            25  C1x C    30.1248  -13.6902
            26  N1y N    28.7834  -14.0760
            27  C1x C    28.7728  -15.4748
            28  C5a C    27.5411  -13.4712
            29  C2b C    27.5362  -12.0916
            30  O5a O    26.3738  -14.2460
            31  C2a C    26.2240  -11.4867
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     7   8 3
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    9  13 1
            15   12  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 2
            20   17  18 1
            21    5  19 1
            22   19  20 1
            23    1  21 1
            24   21  22 1
            25   23  11 1 #Down
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   23  27 1
            31   28  29 1
            32   28  26 1
            33   28  30 2
            34   29  31 2

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