| Entry |
|
|---|
| Name |
Vonoprazan (USAN/INN) |
|---|
| Formula |
C17H16FN3O2S
|
|---|
| Exact mass |
345.0947
|
|---|
| Mol weight |
345.3912
|
|---|
| Structure |
|
|---|
| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG03104): | D10466<JP/US> |
| Product (mixture): | D11804<JP> |
|
|---|
| Efficacy |
Anti-ulcerative, Proton pump inhibitor |
|---|
| Comment |
Potassium competitive acid blocker (P-CAB)
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2B6 [HSA: 1555], CYP2C19 [HSA: 1557], CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC08 Vonoprazan
D11784 Vonoprazan (USAN/INN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG03104 Vonoprazan
D11784 Vonoprazan
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG03104 Vonoprazan
D11784 Vonoprazan
DG01639 CYP2C19 substrate
DG03104 Vonoprazan
D11784 Vonoprazan
DG01644 CYP2D6 substrate
DG03104 Vonoprazan
D11784 Vonoprazan
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03104 Vonoprazan
D11784 Vonoprazan
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D11784 Vonoprazan (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11784
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG03104 Vonoprazan
Metabolizing enzyme substrate
DG02919 CYP2B6 substrate
DG03104 Vonoprazan
DG01639 CYP2C19 substrate
DG03104 Vonoprazan
DG01644 CYP2D6 substrate
DG03104 Vonoprazan
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG03104 Vonoprazan
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 24
1 C8x C 14.1259 -14.8884
2 C8x C 14.1259 -16.2863
3 C8x C 15.3141 -16.9853
4 C8y C 16.5723 -16.2863
5 C8x C 16.5723 -14.8884
6 N5x N 15.3141 -14.1894
7 S4a S 17.7606 -16.9853
8 N4y N 18.9489 -16.2863
9 O3c O 16.7820 -17.9639
10 O3c O 18.7392 -17.9639
11 C8y C 20.2769 -16.7057
12 C8x C 21.1157 -15.5873
13 C8y C 20.2769 -14.5389
14 C8x C 18.9489 -14.9583
15 C8x C 20.2769 -19.0823
16 C8x C 20.9060 -20.3404
17 C8x C 22.3739 -20.3404
18 C8x C 23.1428 -19.1522
19 C8y C 22.4438 -17.8940
20 C8y C 21.0458 -17.8940
21 X F 23.1428 -16.7057
22 C1b C 20.7662 -13.2108
23 N1b N 22.1642 -13.2108
24 C1a C 22.8632 -11.9526
BOND 26
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 7 9 2
10 7 10 2
11 8 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 8 14 1
16 15 16 2
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 2
21 15 20 1
22 20 11 1
23 19 21 1
24 13 22 1
25 22 23 1
26 23 24 1
|
|---|
