KEGG   DRUG: Vutrisiran sodium
Entry
D11916                      Drug                                   
Name
Vutrisiran sodium (JAN);
Amvuttra (TN)
Product
AMVUTTRA (Alnylam Pharmaceuticals)
Formula
C530H672F9N171O323P43S6.43Na
Exact mass
17281.3914
Mol weight
17289.7661
Sequence
(RNA 1) ucuugguuac augaaauccc auc
(RNA 2) ugggauuuca uguaaccaag a
  Type
Nucleotide
Remark
Therapeutic category: 1290
ATC code: N07XX18
Chemical structure group: DG03127
Product (DG03127): D11916<JP/US>
Efficacy
Gene expression regulator
  Disease
Polyneuropathy of hereditary transthyretin-mediated amyloidosis [DS:H00845]
  Type
RNA interference (RNAi) drug
Comment
Treatment of transthyretin (TTR)-mediated amyloidosis (ATTR amyloidosis)
Target
TTR [HSA:7276] [KO:K20731] (mRNA)
  Pathway
hsa04918  Thyroid hormone synthesis
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX18 Vutrisiran
      D11916  Vutrisiran sodium (JAN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Vutrisiran
   D11916  Vutrisiran sodium (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   129  Miscellaneous
    1290  Miscellaneous
     D11916  Vutrisiran sodium (JAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Other transporters
   Others
    TTR
     D11916  Vutrisiran sodium (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11916
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11916
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11916
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11916
LinkDB

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