KEGG   DRUG: Ritlecitinib tosylate
Entry
D11970                      Drug                                   
Name
Ritlecitinib tosylate (USAN);
Ritlecitinib tosilate (JAN);
Litfulo (TN)
Product
LITFULO (Pfizer Laboratories Div Pfizer), LITFULO (U.S. Pharmaceuticals)
Formula
C15H19N5O. C7H8O3S
Exact mass
457.1784
Mol weight
457.5459
Structure
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drug (DMARD)
  DG02020  JAK inhibitor
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Remark
Therapeutic category: 3999
ATC code: L04AF08
Product: D11970<JP/US>
Efficacy
Antirheumatic, Janus kinase (JAK) inhibitor
  Disease
Alopecia areata [DS:H01158]
Target
JAK3 [HSA:3718] [KO:K11218]
  Pathway
hsa04062  Chemokine signaling pathway
hsa04630  JAK-STAT signaling pathway
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP1A2 [HSA:1544]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AF Janus-associated kinase (JAK) inhibitors
     L04AF08 Ritlecitinib
      D11970  Ritlecitinib tosylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunological Agents, Other
   JAK Inhibitors
    Ritlecitinib
     D11970  Ritlecitinib tosylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D11970  Ritlecitinib tosylate (USAN); Ritlecitinib tosilate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG02020  JAK inhibitor
    D11970  Ritlecitinib tosylate
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   D11970  Ritlecitinib tosylate
  DG02852  CYP3A/CYP3A4 inhibitor
   D11970  Ritlecitinib tosylate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Non-receptor tyrosine kinases
   JAK family
    JAK3
     D11970  Ritlecitinib tosylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11970
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11970
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11970
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11970
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11970
Other DBs
CAS: 2192215-81-7
ChEBI: 229234
LinkDB
KCF data

ATOM        32
            1   N1y N    17.6119  -17.4763
            2   C1y C    17.6119  -18.8804
            3   C1x C    16.4184  -19.5825
            4   C1x C    15.1546  -18.8804
            5   C1y C    15.1546  -17.4763
            6   C1x C    16.4184  -16.7742
            7   C5a C    18.8054  -16.7742
            8   C2b C    19.9990  -17.4763
            9   O5a O    18.8054  -15.3700
            10  C2a C    21.1925  -16.7742
            11  N1b N    13.9611  -16.7742
            12  C8y C    13.9611  -15.3700
            13  C8y C    12.7675  -14.6679
            14  C8y C    12.7675  -13.2638
            15  N5x N    13.9611  -12.5617
            16  C8x C    15.1546  -13.2638
            17  N5x N    15.1546  -14.6679
            18  C8x C    11.4336  -15.0892
            19  C8x C    10.5911  -13.9659
            20  N4x N    11.4336  -12.8425
            21  C1a C    18.8054  -19.5825
            22  C8x C    24.1413  -16.2827
            23  C8x C    24.1413  -17.6869
            24  C8y C    25.3573  -18.3890
            25  C8x C    26.5734  -17.6869
            26  C8x C    26.5734  -16.2827
            27  C8y C    25.3573  -15.5806
            28  C1a C    25.3573  -19.7930
            29  S4a S    25.3573  -14.1767
            30  O1d O    23.9531  -14.1767
            31  O1d O    26.7615  -14.1767
            32  O1d O    25.3573  -12.7725
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     7   9 2
            10    8  10 2
            11    5  11 1 #Up
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   12  17 1
            19   13  18 1
            20   18  19 2
            21   19  20 1
            22   14  20 1
            23    2  21 1 #Up
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1
            30   24  28 1
            31   27  29 1
            32   29  30 2
            33   29  31 2
            34   29  32 1

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