KEGG   DRUG: Fezolinetant
Entry
D11976                      Drug                                   
Name
Fezolinetant (USAN);
Veozah (TN)
Product
VEOZAH (Astellas Pharma US)
Formula
C16H15FN6OS
Exact mass
358.1012
Mol weight
358.3933
Structure
Class
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
Remark
ATC code: G02CX06
Product: D11976<US>
Efficacy
Hormone modulator, Tachykinin receptor 3 antagonist
Comment
Treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause
Target
TACR3 (NK3R) [HSA:6870] [KO:K04224]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP1A2 [HSA:1544]; CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CX Other gynecologicals
     G02CX06 Fezolinetant
      D11976  Fezolinetant (USAN) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Central Nervous System, Other
   Fezolinetant
    D11976  Fezolinetant (USAN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   D11976  Fezolinetant
  DG01642  CYP2C9 substrate
   D11976  Fezolinetant
  DG01639  CYP2C19 substrate
   D11976  Fezolinetant
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Tachykinin
    TACR3 (NK3R)
     D11976  Fezolinetant (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11976
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11976
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11976
Other DBs
CAS: 1629229-37-3
ChEBI: 229236
LinkDB
KCF data

ATOM        25
            1   C8y C    21.7700  -16.3100
            2   C8x C    21.7700  -17.7100
            3   C8x C    20.5800  -18.4100
            4   C8y C    19.3200  -17.7100
            5   C8x C    19.3200  -16.3100
            6   C8x C    20.5800  -15.6100
            7   C5a C    22.9600  -15.6100
            8   N1y N    24.1500  -16.3100
            9   C1x C    25.3400  -15.6100
            10  C1x C    26.6000  -16.3100
            11  N4y N    26.6000  -17.7100
            12  C8y C    25.4100  -18.4100
            13  C1y C    24.1500  -17.7100
            14  O5a O    22.9600  -14.2100
            15  X   F    18.1300  -18.4100
            16  C1a C    22.9600  -18.4100
            17  C8y C    27.5800  -18.6200
            18  N5x N    27.0200  -19.8800
            19  N5x N    25.6900  -19.7400
            20  C8y C    28.9800  -18.3400
            21  N5x N    29.5400  -17.0800
            22  C8y C    30.9400  -17.2200
            23  N5x N    31.2200  -18.5500
            24  S2x S    30.0300  -19.3200
            25  C1a C    31.8500  -16.1700
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15    7  14 2
            16    4  15 1
            17   13  16 1
            18   11  17 1
            19   17  18 2
            20   18  19 1
            21   12  19 2
            22   17  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   20  24 1
            28   22  25 1

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