KEGG   DRUG: Efbemalenograstim alfa
Entry
D11986                      Drug                                   
Name
Efbemalenograstim alfa (USAN/INN);
Efbemalenograstim alfa-vuxw;
Ryzneuta (TN)
Product
RYZNEUTA (Evive Biotechnology Singapore PTE.)
Sequence
TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP
LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ
MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQPGSGGGS
GGGGSGGGGS VECPPCPAPP VAGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVQ
FNWYVDGVEV HNAKTKPREE QFNSTFRVVS VLTVVHQDWL NGKEYKCKVS NKGLPASIEK
TISKTKGQPR EPQVYTLPPS REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT
PPMLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN YTQKSLSLS PGK
(Disulfide bridge: 36-42, 64-74, 193-193', 196-196', 227-287, 333-391, 36'-42', 64'-74', 227'-287', 333'-391')
  Type
Peptide
Class
Immunological agent
 DG01753  Colony stimulating factor
  DG01781  Granulocyte colony stimulating factor (G-CSF)
Remark
ATC code: L03AA18
Product: D11986<US>
Efficacy
Antineutropenic, Granulocyte colony stimulating factor (G-CSF)
  Disease
Febrile neutropenia [DS:H00100]
Comment
Treatment to reduce the risk of febrile infection and neutropenia
Target
CSF3R (GCSFR, CD114) [HSA:1441] [KO:K05061]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04640  Hematopoietic cell lineage
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AA Colony stimulating factors
     L03AA18 Efbemalenograstim alfa
      D11986  Efbemalenograstim alfa (USAN/INN) <US>
Drug groups [BR:br08330]
 Immunological agent
  DG01753  Colony stimulating factor
   DG01781  Granulocyte colony stimulating factor (G-CSF)
    D11986  Efbemalenograstim alfa
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    CSF3R (GCSFR, CD114)
     D11986  Efbemalenograstim alfa (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11986
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11986
Other DBs
CAS: 2200269-79-8
LinkDB

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