KEGG   DRUG: Tebentafusp
Entry
D12296                      Drug                                   
Name
Tebentafusp (USAN/INN);
Tebentafusp-tebn;
Kimmtrak (TN)
Product
KIMMTRAK (Immunocore Commercial LLC)
Sequence
(Heavy chain)
AIQMTQSPSS LSASVGDRVT ITCRASQDIR NYLNWYQQKP GKAPKLLIYY TSRLESGVPS
RFSGSGSGTD YTLTISSLQP EDFATYYCQQ GNTLPWTFGQ GTKVEIKGGG GSGGGGSGGG
GSGGGGSGGG SEVQLVESGG GLVQPGGSLR LSCAASGYSF TGYTMNWVRQ APGKGLEWVA
LINPYKGVST YNQKFKDRFT ISVDKSKNTA YLQMNSLRAE DTAVYYCARS GYYGDSDWYF
DVWGQGTLVT VSSGGGGSDG GITQSPKYLF RKEGQNVTLS CEQNLNHDAM YWYRQDPGQG
LRLIYYSWAQ GDFQKGDIAE GYSVSREKKE SFPLTVTSAQ KNPTAFYLCA SSWGAPYEQY
FGPGTRLTVT EDLKNVFPPE VAVFEPSEAE ISHTQKATLV CLATGFYPDH VELSWWVNGK
EVHSGVCTDP QPLKEQPALN DSRYALSSRL RVSATFWQDP RNHFRCQVQF YGLSENDEWT
QDRAKPVTQI VSAEAWGRAD
(Light chain)
AQQGEEDPQA LSIQEGENAT MNCSYKTSIN NLQWYRQNSG RGLVHLILIR SNEREKHSGR
LRVTLDTSKK SSSLLITASR AADTASYFCA TDGSTPMQFG KGTRLSVIAN IQKPDPAVYQ
LRDSKSSDKS VCLFTDFDSQ TNVSQSKDSD VYITDKCVLD MRSMDFKSNS AVAWSNKSDF
ACANAFNNSI IPEDT
(Disulfide bridge: H23-H88, H153-H227, H281-H349, H401-H466, H427-L157, L23-L89, L132-L182)
  Type
Peptide
Remark
ATC code: L01XX75
Product: D12296<US>
Efficacy
Antineoplastic
  Disease
Uveal melanoma (HLA-A*02:01-positive) [DS:H00038]
Comment
Fusion protein
Treatment of uveal melanoma
Target
CD3 [HSA:915 916 917] [KO:K06450 K06451 K06452]
PMEL (gp100) [HSA:6490] [KO:K17304]
  Pathway
hsa04660  T cell receptor signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX75 Tebentafusp
      D12296  Tebentafusp (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Tebentafusp
    D12296  Tebentafusp (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD3
     D12296  Tebentafusp (USAN/INN) <US>
 Not elsewhere classified
  Cellular process
   Membrane trafficking
    PMEL (gp100)
     D12296  Tebentafusp (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12296
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12296
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12296
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D12296
Other DBs
CAS: 1874157-95-5
LinkDB

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