KEGG   DRUG: Codeine phosphate and chlorpheniramine maleate
Entry
D12312            Mixture   Drug                                   
Name
Codeine phosphate and chlorpheniramine maleate;
Tuxarin (TN)
Product
TUXARIN (Mainpointe Pharmaceuticals)
Component
Codeine phosphate [DR:D02101], Chlorpheniramine maleate [DR:D00665]
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
  DG03189  UGT2B4 substrate
  DG03190  UGT2B7 substrate
Remark
ATC code: R05DA20
Product: D12312<US>
Efficacy
Antitussive
Comment
Dihydrocodeine phosphate is metabolized by UGT2B7, UGT2B4 with some contribution from CYP3A4 and CYP2D6.
Chlorpheniramine is metabolized by CYP2D6.
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363]; CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R05 COUGH AND COLD PREPARATIONS
   R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
    R05DA Opium alkaloids and derivatives
     R05DA20 Combinations
      D12312  Codeine phosphate and chlorpheniramine maleate <US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Cold-Cough
   Chlorpheniramine Maleate/ Codeine Phosphate
    D12312  Codeine phosphate and chlorpheniramine maleate
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D12312  Codeine phosphate and chlorpheniramine maleate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D12312  Codeine phosphate and chlorpheniramine maleate
  DG02924  UGT substrate
   DG03189  UGT2B4 substrate
    D12312  Codeine phosphate and chlorpheniramine maleate
   DG03190  UGT2B7 substrate
    D12312  Codeine phosphate and chlorpheniramine maleate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12312
Other DBs
CAS: 60540-98-9
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system