KEGG   DRUG: Mifepristone and misoprostol
Entry
D12586            Mixture   Drug                                   
Name
Mifepristone and misoprostol;
Mefeego (TN)
Component
Mifepristone [DR:D00585], Misoprostol [DR:D00419]
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Remark
Therapeutic category: 2499
ATC code: G03XB51
Product: D12586<JP>
Efficacy
Abortifacient
Comment
Mifepristone is a substrate and an inhibitor of CYP3A.
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03X OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
    G03XB Progesterone receptor modulators
     G03XB51 Mifepristone, combinations
      D12586  Mifepristone and misoprostol <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D12586  Mifepristone and misoprostol
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D12586  Mifepristone and misoprostol
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   D12586  Mifepristone and misoprostol
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12586
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12586
LinkDB

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