| Entry |
|
|---|
| Name |
Flizasertib (USAN/INN) |
|---|
| Formula |
C15H14FN3O
|
|---|
| Exact mass |
271.1121
|
|---|
| Mol weight |
271.2896
|
|---|
| Structure |
|
|---|
| Efficacy |
Anti-inflammatory, Autoimmune disease treatment, Receptor interacting serine/ threonine kinase 1 inhibitor |
|---|
| Comment |
Treatment of inflammatory and autoimmune diseases and disorders
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04622 | RIG-I-like receptor signaling pathway |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Protein kinases
Serine/threonine kinases
TKL group
RIPK1
D12821 Flizasertib (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 20
1 C8y C 20.0200 -18.4800
2 N4y N 20.0200 -17.0800
3 N5x N 18.6900 -16.6600
4 C8y C 17.8500 -17.7800
5 N5x N 18.6900 -18.9000
6 C1y C 21.4200 -18.9000
7 C1x C 22.2600 -17.7800
8 C1y C 21.4200 -16.6600
9 C8y C 21.8400 -15.3300
10 C8x C 23.2400 -15.0500
11 C8x C 23.6600 -13.7200
12 C8x C 22.6800 -12.6700
13 C8x C 21.3500 -12.9500
14 C8x C 20.8600 -14.2800
15 X F 21.8400 -20.2300
16 C5a C 16.4500 -17.7800
17 O5a O 15.7500 -16.5900
18 C1y C 15.7500 -18.9700
19 C1x C 15.6800 -20.3700
20 C1x C 14.4900 -19.6700
BOND 23
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 1 5 2
6 1 6 1
7 6 7 1
8 7 8 1
9 2 8 1
10 8 9 1 #Down
11 9 10 2
12 10 11 1
13 11 12 2
14 12 13 1
15 13 14 2
16 9 14 1
17 6 15 1 #Down
18 4 16 1
19 16 17 2
20 16 18 1
21 18 20 1
22 20 19 1
23 19 18 1
|
|---|
