Helicobacter pylori (HP) is a gram-negative pathogenic bacterium that specifically colonizes in the gastric epithelium and causes chronic gastritis, peptic ulcer disease, and/or gastric malignancies. Persistent infection can cause inflammation and gastritis that may lead to carcinogenesis. Transmission is still not entirely clarified, but human-to-human spread through oral-oral or fecal-oral route is thought to be the most plausible. The prevalence of HP infection varies between different geographical regions; generally, the prevalence is about 30% in developed and up to 80% in developing countries. Although HP may sometimes be eradicated by antibiotics given for other infections, infection usually persists life-long unless specific combination antibiotic therapy is taken.
Category
Bacterial infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
13 Diseases of the digestive system
Diseases of the stomach or the duodenum
Diseases of duodenum
DA51 Duodenitis
H00320 Helicobacter pylori infection
Ulcer of stomach or duodenum
DA60 Gastric ulcer
H00320 Helicobacter pylori infection
DA62 Anastomotic ulcer
H00320 Helicobacter pylori infection
DA63 Duodenal ulcer
H00320 Helicobacter pylori infection
Genome-based classification of infectious diseases [BR:br08401]
Bacterial infections
Infections caused by epsilon proteobacteria
H00320 Helicobacter pylori infection
