KEGG   DISEASE: Hepatitis C
Entry
H00413                      Disease                                
Name
Hepatitis C;
Hepatitis C virus (HCV) infection
  Supergrp
Viral hepatitis [DS:H02162]
Fulminant hepatic failure [DS:H01712]
Description
Hepatitis C is a blood-borne infectious disease caused by Hepatitis C virus (HCV) belonging to the Flaviviridae family of +ssRNA viruses. HCV infection often becomes chronic and can lead to degenerative liver diseases including fibrosis and cirrhosis. Some of these may eventually lead to hepatocellular carcinoma.
Category
Viral infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Viral hepatitis
   1E50  Acute viral hepatitis
    H00413  Hepatitis C
   1E51  Chronic viral hepatitis
    H00413  Hepatitis C
Genome-based classification of infectious diseases [BR:br08401]
 Viral infections
  Infections caused by +ssRNA viruses
   H00413  Hepatitis C
Disease
pathway
hsa05160  Hepatitis C
Network
nt06163 Hepatitis C virus (HCV)
Gene
CCR5 (resistance) [HSA:1234] [KO:K04180]
PTPRC (susceptibility) [HSA:5788] [KO:K06478]
Pathogen
Hepatitis C virus (HCV) [GN:T40066]
Drug
Ribavirin [DR:D00423]
Simeprevir sodium [DR:D10469]
Sofosbuvir [DR:D10366]
Ledipasvir and sofosbuvir [DR:D10578]
Dasabuvir, ombitasvir, paritaprevir and ritonavir [DR:D10582]
Ombitasvir, paritaprevir and ritonavir [DR:D10745]
Elbasvir and grazoprevir [DR:D10778]
Sofosbuvir and velpatasvir [DR:D10827]
Sofosbuvir, velpatasvir and voxilaprevir [DR:D10900]
Glecaprevir and pibrentasvir [DR:D11014]
Interferon alfa-2b [DR:D02745]
Peginterferon alfa-2b [DR:D02748]
Peginterferon alfa-2a [DR:D02747]
Other DBs
ICD-11: 1E50.2 1E51.1
ICD-10: B17.1
MeSH: D006526
MedlinePlus: 000284
OMIM: 609532
Reference
PMID:26600216
  Authors
Lingala S, Ghany MG
  Title
Natural History of Hepatitis C.
  Journal
Gastroenterol Clin North Am 44:717-34 (2015)
DOI:10.1016/j.gtc.2015.07.003
Reference
PMID:25071320
  Authors
Lee MH, Yang HI, Yuan Y, L'Italien G, Chen CJ
  Title
Epidemiology and natural history of hepatitis C virus infection.
  Journal
World J Gastroenterol 20:9270-80 (2014)
DOI:10.3748/wjg.v20.i28.9270
Reference
PMID:15863470 (CCR5)
  Authors
Goulding C, McManus R, Murphy A, MacDonald G, Barrett S, Crowe J, Hegarty J, McKiernan S, Kelleher D
  Title
The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source.
  Journal
Gut 54:1157-61 (2005)
DOI:10.1136/gut.2004.055699
Reference
PMID:16505159 (PTPRC)
  Authors
Dawes R, Hennig B, Irving W, Petrova S, Boxall S, Ward V, Wallace D, Macallan DC, Thursz M, Hill A, Bodmer W, Beverley PC, Tchilian EZ
  Title
Altered CD45 expression in C77G carriers influences immune function and outcome of hepatitis C infection.
  Journal
J Med Genet 43:678-84 (2006)
DOI:10.1136/jmg.2005.040485
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