KEGG   DISEASE: Pyogenic bacterial infections, recurrent, due to MYD88 deficiency
Entry
H00721                      Disease                                
Name
Pyogenic bacterial infections, recurrent, due to MYD88 deficiency
Description
Autosomal recessive MyD88 deficiency predisposes affected patients to recurrent pyogenic bacterial infections, including invasive pneumococcal disease. The patients are resistant to other microbes.
Category
Immune system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 04 Diseases of the immune system
  Primary immunodeficiencies
   4A00  Primary immunodeficiencies due to disorders of innate immunity
    H00721  Pyogenic bacterial infections, recurrent, due to MYD88 deficiency
Pathway
hsa04620 Toll-like receptor signaling pathway   
hsa04010 MAPK signaling pathway   
Gene
MYD88 [HSA:4615] [KO:K04729]
Other DBs
ICD-11: 4A00.2
MeSH: C567379
OMIM: 612260
Reference
PMID:18669862
  Authors
von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL
  Title
Pyogenic bacterial infections in humans with MyD88 deficiency.
  Journal
Science 321:691-6 (2008)
DOI:10.1126/science.1158298
Reference
PMID:21734245
  Authors
Picard C, Casanova JL, Puel A
  Title
Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IkappaBalpha deficiency.
  Journal
Clin Microbiol Rev 24:490-7 (2011)
DOI:10.1128/CMR.00001-11
Reference
PMID:20236864
  Authors
Bousfiha A, Picard C, Boisson-Dupuis S, Zhang SY, Bustamante J, Puel A, Jouanguy E, Ailal F, El-Baghdadi J, Abel L, Casanova JL
  Title
Primary immunodeficiencies of protective immunity to primary infections.
  Journal
Clin Immunol 135:204-9 (2010)
DOI:10.1016/j.clim.2010.02.001
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