KEGG   DISEASE: Adiponectin deficiency
Entry
H00967                      Disease                                
Name
Adiponectin deficiency
Description
Adiponectin is a major adipocyte-derived protein with insulin-sensitizing, anti-inflammatory and anti-atherogenic properties. Adiponectin deficiency (ADPOD) related to several obesity related malignancies including colorectal cancer.
Category
Inherited metabolic disorder
Brite
Human diseases in ICD-11 classification [BR:br08403]
 05 Endocrine, nutritional or metabolic diseases
  Metabolic disorders
   Inborn errors of metabolism
    5C5Y  Other specified inborn errors of metabolism
     H00967  Adiponectin deficiency
Pathway-based classification of diseases [BR:br08402]
 Endocrine system
  nt06325  Hormone/cytokine signaling
   H00967  Adiponectin deficiency
Pathway
hsa04920  Adipocytokine signaling pathway
Network
nt06325 Hormone/cytokine signaling
Gene
ADIPOQ [HSA:9370] [KO:K07296]
Other DBs
ICD-11: 5C5Y
MeSH: C567258
OMIM: 612556
Reference
PMID:22198319
  Authors
Saxena A, Chumanevich A, Fletcher E, Larsen B, Lattwein K, Kaur K, Fayad R
  Title
Adiponectin deficiency: role in chronic inflammation induced colon cancer.
  Journal
Biochim Biophys Acta 1822:527-36 (2012)
DOI:10.1016/j.bbadis.2011.12.006
Reference
PMID:10918532 (ADIPOQ)
  Authors
Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, Shimomura I, Hotta K, Kuriyama H, Kihara S, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y
  Title
Genomic structure and mutations in adipose-specific gene, adiponectin.
  Journal
Int J Obes Relat Metab Disord 24:861-8 (2000)
DOI:10.1038/sj.ijo.0801244
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