KEGG   DISEASE: Schistosomiasis
Entry
H01045                      Disease                                
Name
Schistosomiasis
Description
Schistosomiasis is a parasitic disease caused by trematode worms of the genus Schistosoma. Schistosomiasis is one of the most devastating tropical diseases in the world, and WHO estimates 600 million people at risk of infection with 200 million infected. Among nonimmune patients, host's immune response to schistosome eggs leads to acute schistosomiasis that is characterized by cercarial dermatitis and Katayama fever. Life-threatening cardiac and neurological complications may occur. Schistosome eggs can also lead to chronic fibrotic response in host tissues, causing gastrointestinal and liver diseases.
Category
Parasitic infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Parasitic diseases
   Helminthiases
    Diseases due to trematodes
     1F86  Schistosomiasis
      H01045  Schistosomiasis
Genome-based classification of infectious diseases [BR:br08401]
 Parasitic infections (animals)
  Infections caused by flat worms
   H01045  Schistosomiasis
Pathogen
Schistosoma mansoni [GN:smm]
Schistosoma haematobium [GN:shx]
Schistosoma japonicum
Drug
Praziquantel [DR:D00471]
Other DBs
ICD-11: 1F86
ICD-10: B65
MeSH: D012552
Reference
  Authors
Burke ML, Jones MK, Gobert GN, Li YS, Ellis MK, McManus DP
  Title
Immunopathogenesis of human schistosomiasis.
  Journal
Parasite Immunol 31:163-76 (2009)
DOI:10.1111/j.1365-3024.2009.01098.x
Reference
  Authors
Wilson MS, Mentink-Kane MM, Pesce JT, Ramalingam TR, Thompson R, Wynn TA
  Title
Immunopathology of schistosomiasis.
  Journal
Immunol Cell Biol 85:148-54 (2007)
DOI:10.1038/sj.icb.7100014
Reference
  Authors
Jaureguiberry S, Paris L, Caumes E
  Title
Acute schistosomiasis, a diagnostic and therapeutic challenge.
  Journal
Clin Microbiol Infect 16:225-31 (2010)
DOI:10.1111/j.1469-0691.2009.03131.x
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