KEGG   DISEASE: Vaccinia
Entry
H02352                      Disease                                
Name
Vaccinia
Description
Vaccinia is an infectious disease caused by vaccinia virus, an orthopoxvirus in the Poxviridae family of dsDNA viruses. Vaccinia virus has been used as a smallpox vaccine. Several serious complications such as encephalitis, progressive vaccinia, eczema vaccinatum, and generalized vaccinia and disseminated vaccinia have been reported.
Category
Viral infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Viral infections characterised by skin or mucous membrane lesions
   Infections due to poxvirus
    1E73  Vaccinia
     H02352  Vaccinia
Genome-based classification of infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H02352  Vaccinia
Pathogen
Vaccinia virus [GN:T40360]
Drug
Vaccinia immune globulin [DR:D06271]
Comment
After smallpox was declared eradicated, the vaccination was discontinued, favoring a new contingent of susceptible individuals to orthopoxviruses.
Other DBs
ICD-11: 1E73
MeSH: D014615
Reference
PMID:12742570
  Authors
Bray M
  Title
Pathogenesis and potential antiviral therapy of complications of smallpox vaccination.
  Journal
Antiviral Res 58:101-14 (2003)
DOI:10.1016/s0166-3542(03)00008-1
Reference
PMID:12911836
  Authors
Aragon TJ, Ulrich S, Fernyak S, Rutherford GW
  Title
Risks of serious complications and death from smallpox vaccination: a systematic review of the United States experience, 1963-1968.
  Journal
BMC Public Health 3:26 (2003)
DOI:10.1186/1471-2458-3-26
Reference
PMID:19828265
  Authors
Essbauer S, Pfeffer M, Meyer H
  Title
Zoonotic poxviruses.
  Journal
Vet Microbiol 140:229-36 (2010)
DOI:10.1016/j.vetmic.2009.08.026
Reference
PMID:29140260
  Authors
Oliveira JS, Figueiredo PO, Costa GB, Assis FL, Drumond BP, da Fonseca FG, Nogueira ML, Kroon EG, Trindade GS
  Title
Vaccinia Virus Natural Infections in Brazil: The Good, the Bad, and the Ugly.
  Journal
Viruses 9:E340 (2017)
DOI:10.3390/v9110340
Reference
PMID:21854314
  Authors
Walsh SR, Dolin R
  Title
Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors.
  Journal
Expert Rev Vaccines 10:1221-40 (2011)
DOI:10.1586/erv.11.79
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