KEGG   NETWORK: N00019
Entry
N00019                      Network                                
Name
FGF-FGFR-RAS-ERK signaling pathway
Definition
FGF -> FGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
(2246,2247,2248,2249,2250,2251,2252,2253,2254,2255,8823,8822,8817,9965,26281,26291,27006,8074) -> (2260,2263,2261,2264) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06261 Gastric cancer
nt06265 Bladder cancer
nt06270 Breast cancer
nt06210 ERK signaling (cancer)
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
2246  FGF1; fibroblast growth factor 1
2247  FGF2; fibroblast growth factor 2
2248  FGF3; fibroblast growth factor 3
2249  FGF4; fibroblast growth factor 4
2250  FGF5; fibroblast growth factor 5
2251  FGF6; fibroblast growth factor 6
2252  FGF7; fibroblast growth factor 7
2253  FGF8; fibroblast growth factor 8
2254  FGF9; fibroblast growth factor 9
2255  FGF10; fibroblast growth factor 10
8823  FGF16; fibroblast growth factor 16
8822  FGF17; fibroblast growth factor 17
8817  FGF18; fibroblast growth factor 18
9965  FGF19; fibroblast growth factor 19
26281  FGF20; fibroblast growth factor 20
26291  FGF21; fibroblast growth factor 21
27006  FGF22; fibroblast growth factor 22
8074  FGF23; fibroblast growth factor 23
2260  FGFR1; fibroblast growth factor receptor 1
2263  FGFR2; fibroblast growth factor receptor 2
2261  FGFR3; fibroblast growth factor receptor 3
2264  FGFR4; fibroblast growth factor receptor 4
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
PMID:17409820
  Authors
Molina JR, Adjei AA
  Title
The Ras/Raf/MAPK pathway.
  Journal
J Thorac Oncol 1:7-9 (2006)
DOI:10.1016/S1556-0864(15)31506-9
Reference
PMID:23403721
  Authors
Goetz R, Mohammadi M
  Title
Exploring mechanisms of FGF signalling through the lens of structural biology.
  Journal
Nat Rev Mol Cell Biol 14:166-80 (2013)
DOI:10.1038/nrm3528
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