KEGG   NETWORK: N00028
Entry
N00028                      Network                                
Name
PDGF-PDGFR-PLCG-CAMK signaling pathway
Definition
PDGF -> PDGFR -> PLCG -> IP3 -> Ca2+ -> CALM == CAMK
  Expanded
(5154,5155) -> (5156,5159) -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) == (8536,57118,57172,815,816,817,818,814)
Class
nt06273 Glioma
nt06220 Calcium signaling (cancer)
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
5154  PDGFA; platelet derived growth factor subunit A
5155  PDGFB; platelet derived growth factor subunit B
5156  PDGFRA; platelet derived growth factor receptor alpha
5159  PDGFRB; platelet derived growth factor receptor beta
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
8536  CAMK1; calcium/calmodulin dependent protein kinase I
57118  CAMK1D; calcium/calmodulin dependent protein kinase ID
57172  CAMK1G; calcium/calmodulin dependent protein kinase IG
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma
814  CAMK4; calcium/calmodulin dependent protein kinase IV
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
PMID:2333512
  Authors
Margolis B, Zilberstein A, Franks C, Felder S, Kremer S, Ullrich A, Rhee SG, Skorecki K, Schlessinger J
  Title
Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis.
  Journal
Science 248:607-10 (1990)
DOI:10.1126/science.2333512
Reference
PMID:10220508
  Authors
Di Sario A, Bendia E, Svegliati Baroni G, Ridolfi F, Bolognini L, Feliciangeli G, Jezequel AM, Orlandi F, Benedetti A
  Title
Intracellular pathways mediating Na+/H+ exchange activation by platelet-derived growth factor in rat hepatic stellate cells.
  Journal
Gastroenterology 116:1155-66 (1999)
DOI:10.1016/S0016-5085(99)70019-3
Reference
PMID:22435804
  Authors
Berridge MJ
  Title
Calcium signalling remodelling and disease.
  Journal
Biochem Soc Trans 40:297-309 (2012)
DOI:10.1042/BST20110766
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