KEGG   NETWORK: N00044
Entry
N00044                      Network                                
Name
Mutation-activated MET to PI3K signaling pathway
Definition
MET* -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
4233v1 -> 2549 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06263 Hepatocellular carcinoma
nt06264 Renal cell carcinoma
nt06214 PI3K signaling (cancer)
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
hsa05211  Renal cell carcinoma
Disease
H00048  Hepatocellular carcinoma
H00021  Renal cell carcinoma
Gene
4233  MET; MET proto-oncogene, receptor tyrosine kinase
2549  GAB1; GRB2 associated binding protein 1
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Variant
4233v1 (MET*)  MET kinase domain mutation
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14685170
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
PMID:9426201
  Authors
Bardelli A, Pugliese L, Comoglio PM
  Title
"Invasive-growth" signaling by the Met/HGF receptor: the hereditary renal carcinoma connection.
  Journal
Biochim Biophys Acta 1333:M41-51 (1997)
DOI:10.1016/S0304-419X(97)00026-7
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:9927037
  Authors
Park WS, Dong SM, Kim SY, Na EY, Shin MS, Pi JH, Kim BJ, Bae JH, Hong YK, Lee KS, Lee SH, Yoo NJ, Jang JJ, Pack S, Zhuang Z, Schmidt L, Zbar B, Lee JY
  Title
Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.
  Journal
Cancer Res 59:307-10 (1999)
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