| Entry |
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| Name |
Duplication or mutation-activated FLT3 to Jak-STAT signaling pathway
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| Definition |
FLT3* -> STAT5 => PIM1/2 |
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| Expanded |
(2322v2,2322v1) -> (6776,6777) => (5292,11040) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 2322 | FLT3; fms related tyrosine kinase 3 |
| 6776 | STAT5A; signal transducer and activator of transcription 5A |
| 6777 | STAT5B; signal transducer and activator of transcription 5B |
| 5292 | PIM1; Pim-1 proto-oncogene, serine/threonine kinase |
| 11040 | PIM2; Pim-2 proto-oncogene, serine/threonine kinase |
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| Variant |
2322v2 (FLT3*) FLT3 internal tandem duplication (ITD)
2322v1 (FLT3*) FLT3 kinase domain mutation
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| Reference |
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| Authors |
Rocnik JL, Okabe R, Yu JC, Lee BH, Giese N, Schenkein DP, Gilliland DG |
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| Title |
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. |
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| Journal |
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| Reference |
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| Authors |
Choudhary C, Muller-Tidow C, Berdel WE, Serve H. |
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| Title |
Signal transduction of oncogenic Flt3. |
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| Journal |
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| Reference |
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| Authors |
Choudhary C, Brandts C, Schwable J, Tickenbrock L, Sargin B, Ueker A, Bohmer FD, Berdel WE, Muller-Tidow C, Serve H |
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| Title |
Activation mechanisms of STAT5 by oncogenic Flt3-ITD. |
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| Journal |
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| LinkDB |
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