KEGG   NETWORK: N00085
Entry
N00085                      Network                                
Name
Mutation-activated AR to androgen receptor signaling pathway
Definition
(T,DHT,E2,P4,FLUT,DHA,A4,F,E) -> AR* => KLK3
  Expanded
(C00535,C03917,C00951,C00410,C07653,C01227,C00280,C00735,C00762) -> 367v2 => 354
Class
nt06272 Prostate cancer
nt06227 Nuclear receptor signaling (cancer)
Type
Variant
Pathway
hsa05215  Prostate cancer
Disease
H00024  Prostate cancer
Gene
367  AR; androgen receptor
354  KLK3; kallikrein related peptidase 3
Variant
367v2 (AR*)  AR mutation
Metabolite
C00535  Testosterone
C03917  Dihydrotestosterone
C00951  Estradiol-17beta
C00410  Progesterone
C07653  Flutamide
C01227  Dehydroepiandrosterone
C00280  Androstenedione
C00735  Cortisol
C00762  Cortisone
Reference
PMID:12878745
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
PMID:8145761
  Authors
Culig Z, Hobisch A, Cronauer MV, Cato AC, Hittmair A, Radmayr C, Eberle J, Bartsch G, Klocker H
  Title
Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.
  Journal
Mol Endocrinol 7:1541-50 (1993)
DOI:10.1210/mend.7.12.8145761
Reference
PMID:16551847
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
PMID:11900250
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)
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