KEGG   NETWORK: N00093
Entry
N00093                      Network                                
Name
Loss of CDKN1B to p27-cell cycle G1/S
Definition
CDKN1B* // (CCNE+CDK2) -> RB1 // E2F
  Expanded
1027v1 // ((898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06272 Prostate cancer
nt06230 Cell cycle (cancer)
Type
Variant
Pathway
hsa05215  Prostate cancer
Disease
H00024  Prostate cancer
Gene
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
1027v1 (CDKN1B*)  CDKN1B loss
Reference
PMID:10453277
  Authors
Macri E, Loda M.
  Title
Role of p27 in prostate carcinogenesis.
  Journal
Cancer Metastasis Rev 17:337-44 (1998)
DOI:10.1023/A:1006133620914
Reference
PMID:18301781
  Authors
Balk SP, Knudsen KE
  Title
AR, the cell cycle, and prostate cancer.
  Journal
Nucl Recept Signal 6:e001 (2008)
DOI:10.1621/nrs.06001
LinkDB

DBGET integrated database retrieval system