KEGG   NETWORK: N00121
Entry
N00121                      Network                                
Name
LMO2-rearrangement to transcriptional activation
Definition
(LMO2*+LDB1) == (LYL1+TCF3) => HHEX
  Expanded
(4005v1+8861) == (4066+6929) => 3087
Class
nt06240 Transcription (cancer)
Type
Variant
Disease
H00002  T-cell acute lymphoblastic leukemia
Gene
4005  LMO2; LIM domain only 2
8861  LDB1; LIM domain binding 1
4066  LYL1; LYL1, basic helix-loop-helix family member
6929  TCF3; transcription factor 3
3087  HHEX; hematopoietically expressed homeobox
Variant
4005v1 (LMO2*)  LMO2 rearrangement
Reference
PMID:20861166
  Authors
Curtis DJ, McCormack MP
  Title
The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia.
  Journal
Clin Cancer Res 16:5618-23 (2010)
DOI:10.1158/1078-0432.CCR-10-0440
Reference
PMID:16873670
  Authors
Van Vlierberghe P, van Grotel M, Beverloo HB, Lee C, Helgason T, Buijs-Gladdines J, Passier M, van Wering ER, Veerman AJ, Kamps WA, Meijerink JP, Pieters R
  Title
The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia.
  Journal
Blood 108:3520-9 (2006)
DOI:10.1182/blood-2006-04-019927
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