| Entry |
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| Name |
KSHV K15 to TNF-NFKB signaling pathway
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| Definition |
K15 -> TRAF2 -> TAK1 -> IKK -> NFKBIA -> NFKB |
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| Expanded |
K21651 -> 7186 -> 6885 -> (1147+3551+8517) -> 4792 -> (4790+5970) |
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| Class |
nt06516 TNF signaling
nt06223 TNF signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
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| Type |
Pathogen
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| Pathway |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
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| Disease |
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| Gene |
| 7186 | TRAF2; TNF receptor associated factor 2 |
| 6885 | MAP3K7; mitogen-activated protein kinase kinase kinase 7 |
| 1147 | CHUK; conserved helix-loop-helix ubiquitous kinase |
| 3551 | IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta |
| 8517 | IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma |
| 4792 | NFKBIA; NFKB inhibitor alpha |
| 4790 | NFKB1; nuclear factor kappa B subunit 1 |
| 5970 | RELA; RELA proto-oncogene, NF-kB subunit |
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| Perturbant |
| K21651 (K15) | K15; KSHV signal transducing membrane protein |
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| Reference |
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| Authors |
Rahman MM, McFadden G |
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| Title |
Modulation of NF-kappaB signalling by microbial pathogens. |
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| Journal |
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| Reference |
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| Authors |
Abere B, Schulz TF |
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| Title |
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma. |
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| Journal |
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| LinkDB |
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