KEGG   NETWORK: N00180
Entry
N00180                      Network                                
Name
KSHV K1 to PLCG-calcineurin signaling pathway
Definition
K1 -> PLCG2
  Expanded
K21669 -> 5336
Class
nt06220 Calcium signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
5336  PLCG2; phospholipase C gamma 2
Perturbant
K21669 (K1)  K1; KSHV protein K1
Reference
  Authors
Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
  Title
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
  Journal
Rev Med Virol 25:273-85 (2015)
DOI:10.1002/rmv.1843
Reference
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
  Authors
Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
  Title
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
  Journal
Cancer Res 66:3658-66 (2006)
DOI:10.1158/0008-5472.CAN-05-3680
Reference
  Authors
Hogan PG, Chen L, Nardone J, Rao A
  Title
Transcriptional regulation by calcium, calcineurin, and NFAT.
  Journal
Genes Dev 17:2205-32 (2003)
DOI:10.1101/gad.1102703
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