Entry |
|
Name |
EBV EBNA1 to p53-mediated transcription
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Definition |
EBNA1 -| USP7 -> TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK) |
Expanded |
K19461 -| 7874 -> 7157 => (1026,1647,4616,10912,581,578,1643,51426) |
Class |
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Type |
Pathogen
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Pathway |
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Disease |
|
Gene |
7874 | USP7; ubiquitin specific peptidase 7 |
7157 | TP53; tumor protein p53 |
1026 | CDKN1A; cyclin dependent kinase inhibitor 1A |
1647 | GADD45A; growth arrest and DNA damage inducible alpha |
4616 | GADD45B; growth arrest and DNA damage inducible beta |
10912 | GADD45G; growth arrest and DNA damage inducible gamma |
581 | BAX; BCL2 associated X, apoptosis regulator |
578 | BAK1; BCL2 antagonist/killer 1 |
1643 | DDB2; damage specific DNA binding protein 2 |
51426 | POLK; DNA polymerase kappa |
|
Perturbant |
K19461 (EBNA1) | EBNA1; EBV nuclear antigen 1 |
|
Reference |
|
Authors |
Saha A, Robertson ES |
Title |
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes. |
Journal |
|
Reference |
|
Authors |
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L |
Title |
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. |
Journal |
|
Reference |
|
Authors |
Kang H, Kiess A, Chung CH |
Title |
Emerging biomarkers in head and neck cancer in the era of genomics. |
Journal |
|
Reference |
|
Authors |
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM |
Title |
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers. |
Journal |
|
Reference |
|
Authors |
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES |
Title |
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities. |
Journal |
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LinkDB |
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