| Entry |
|
|---|
| Name |
MET-overexpression to PI3K signaling pathway
|
|---|
| Definition |
MET* -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD |
|---|
| Expanded |
4233v2 -> 2549 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
|
|---|
| Disease |
| H00048 | Hepatocellular carcinoma |
|
|---|
| Gene |
| 4233 | MET; MET proto-oncogene, receptor tyrosine kinase |
| 2549 | GAB1; GRB2 associated binding protein 1 |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
|
|---|
| Variant |
4233v2 (MET*) MET overexpression
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Breuhahn K, Longerich T, Schirmacher P |
|---|
| Title |
Dysregulation of growth factor signaling in human hepatocellular carcinoma. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Granito A, Guidetti E, Gramantieri L |
|---|
| Title |
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM. |
|---|
| Title |
Genomics and signaling pathways in hepatocellular carcinoma. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Wickramasinghe D, Kong-Beltran M |
|---|
| Title |
Met activation and receptor dimerization in cancer: a role for the Sema domain. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Gao CF, Vande Woude GF |
|---|
| Title |
HGF/SF-Met signaling in tumor progression. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
