KEGG   NETWORK: N00275
Entry
N00275                      Network                                
Name
Amplified CCND1 to cell cycle G1/S
Definition
(CCND1*+CDK4) -> RB1 // E2F
  Expanded
(595v1+1019) -> 5925 // 1869,1870,1871
Class
nt06270 Breast cancer
nt06230 Cell cycle (cancer)
Type
Variant
Pathway
hsa05224  Breast cancer
Disease
H00031  Breast cancer
Gene
595  CCND1; cyclin D1
1019  CDK4; cyclin dependent kinase 4
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
595v1 (CCND1*)  CCND1 amplification
Reference
PMID:26100274
  Authors
Morikawa A, Henry NL
  Title
Palbociclib for the Treatment of Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer.
  Journal
Clin Cancer Res 21:3591-6 (2015)
DOI:10.1158/1078-0432.CCR-15-0390
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