KEGG   NETWORK: N00318
Entry
N00318                      Network                                
Name
EGFR-ERK-ACTH signaling pathway
Definition
EGFR -> ERK1/2 -> ACTH
  Expanded
1956 -> (5594,5595) -> 5443
Class
nt06310 CRH-ACTH-cortisol signaling
nt06360 Cushing syndrome
Type
Reference
Gene
1956  EGFR; epidermal growth factor receptor
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
5443  POMC; proopiomelanocortin
Reference
  Authors
Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S
  Title
EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas.
  Journal
J Clin Invest 121:4712-21 (2011)
DOI:10.1172/JCI60417
Reference
  Authors
Albani A, Theodoropoulou M, Reincke M
  Title
Genetics of Cushing's disease.
  Journal
Clin Endocrinol (Oxf) 88:3-12 (2018)
DOI:10.1111/cen.13457
Reference
  Authors
Kaiser UB
  Title
Cushing's disease: towards precision medicine.
  Journal
Cell Res 25:649-50 (2015)
DOI:10.1038/cr.2015.53
Reference
  Authors
Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M
  Title
Mutations in the deubiquitinase gene USP8 cause Cushing's disease.
  Journal
Nat Genet 47:31-8 (2015)
DOI:10.1038/ng.3166
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