| Entry |
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| Name |
MAGI-PTEN signaling pathway
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| Definition |
MAGI -> PTEN -| PIP3 -> AKT |
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| Expanded |
(9223,9863) -> 5728 -| C05981 -> (207,208,10000) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 9223 | MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| 9863 | MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 |
| 5728 | PTEN; phosphatase and tensin homolog |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Shin K, Fogg VC, Margolis B |
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| Title |
Tight junctions and cell polarity. |
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| Journal |
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| Reference |
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| Authors |
Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE |
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| Title |
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. |
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| Journal |
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| Reference |
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| Authors |
Subauste MC, Nalbant P, Adamson ED, Hahn KM |
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| Title |
Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. |
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| Journal |
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| Reference |
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| Authors |
Tolkacheva T, Boddapati M, Sanfiz A, Tsuchida K, Kimmelman AC, Chan AM |
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| Title |
Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383. |
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| Journal |
Cancer Res 61:4985-9 (2001) |
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| LinkDB |
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