KEGG   NETWORK: N00360
Entry
N00360                      Network                                
Name
HPV E7 to p27-cell cycle G1/S
Definition
E7 -> (CCNE+CDK2) -> RB1 // E2F
  Expanded
K21809 -> ((898,9134)+1017) -> 5925 // (1869,1870,1871)
Class
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
898  CCNE1; cyclin E1
9134  CCNE2; cyclin E2
1017  CDK2; cyclin dependent kinase 2
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21809 (E7)  E7; HPV protein E7
Reference
PMID:12044013
  Authors
Boshoff C, Weiss R
  Title
AIDS-related malignancies.
  Journal
Nat Rev Cancer 2:373-82 (2002)
DOI:10.1038/nrc797
Reference
PMID:19684440
  Authors
Lehoux M, D'Abramo CM, Archambault J
  Title
Molecular mechanisms of human papillomavirus-induced carcinogenesis.
  Journal
Public Health Genomics 12:268-80 (2009)
DOI:10.1159/000214918
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