KEGG   NETWORK: N00374
Entry
N00374                      Network                                
Name
TNF-IRF1 signaling pathway
Definition
TNF -> TNFRSF1B -> IRF1 => IFNB1
  Expanded
7124 -> 7133 -> 3659 => 3456
Class
nt06516 TNF signaling
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04668  TNF signaling pathway
Gene
7124  TNF; tumor necrosis factor
7133  TNFRSF1B; TNF receptor superfamily member 1B
3659  IRF1; interferon regulatory factor 1
3456  IFNB1; interferon beta 1
Reference
PMID:23623383
  Authors
Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, Garcia-Cardena G, Horwitz BH, Mayadas TN
  Title
Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-beta autocrine signaling to promote monocyte recruitment.
  Journal
Immunity 38:1025-37 (2013)
DOI:10.1016/j.immuni.2013.01.012
Reference
PMID:25140911
  Authors
Al-Lamki RS, Mayadas TN
  Title
TNF receptors: signaling pathways and contribution to renal dysfunction.
  Journal
Kidney Int 87:281-96 (2015)
DOI:10.1038/ki.2014.285
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