Entry Name HPV E6 to Notch signaling pathway
Definition E6 -> (NFX1+PSEN1) -> NOTCH -> (NICD+RBPJ+MAML) => (HES1,HEY1)
Expanded K21807 -> (4799+5663) -> (4851,4853,4854,4855) -> (C22528+(3516,11317)+(9794,84441,55534)) => (3280,23462)
Class Type Pathogen
Pathway Disease Gene 4799 NFX1; nuclear transcription factor, X-box binding 1
3516 RBPJ; recombination signal binding protein for immunoglobulin kappa J region
11317 RBPJL; recombination signal binding protein for immunoglobulin kappa J region like
9794 MAML1; mastermind like transcriptional coactivator 1
84441 MAML2; mastermind like transcriptional coactivator 2
55534 MAML3; mastermind like transcriptional coactivator 3
3280 HES1; hes family bHLH transcription factor 1
23462 HEY1; hes related family bHLH transcription factor with YRPW motif 1
Perturbant K21807 (E6) E6; HPV protein E6
Metabolite C22528 Notch intracellular domain
Reference Authors Chen J
Title Signaling pathways in HPV-associated cancers and therapeutic implications.
Journal Reference Authors Veeraraghavalu K, Pett M, Kumar RV, Nair P, Rangarajan A, Stanley MA, Krishna S
Title Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation.
Journal Reference Authors Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA
Title NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.
Journal LinkDB All DBs
