NETWORK: N00399
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Entry
N00399 Network
Name
CCR2-GNB/G-PI3K-NFKB signaling pathway
Definition
CCL2 -> CCR2 -> GNB/G -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB
Expanded
6347 -> 729230 -> (2782,
2783,
2784,
59345,
10681,
54331,
2785,
2786,
2787,
2788,
94235,
2790,
2791,
55970,
51764,
2792,
2793) -> (5290,
5291,
5293) -> C05981 -> (207,
208,
10000) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06167
Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04062
Chemokine signaling pathway
Gene
6347
CCL2; C-C motif chemokine ligand 2
729230
CCR2; C-C motif chemokine receptor 2
2782
GNB1; G protein subunit beta 1
2783
GNB2; G protein subunit beta 2
2784
GNB3; G protein subunit beta 3
59345
GNB4; G protein subunit beta 4
10681
GNB5; G protein subunit beta 5
54331
GNG2; G protein subunit gamma 2
2785
GNG3; G protein subunit gamma 3
2786
GNG4; G protein subunit gamma 4
2787
GNG5; G protein subunit gamma 5
2788
GNG7; G protein subunit gamma 7
94235
GNG8; G protein subunit gamma 8
2790
GNG10; G protein subunit gamma 10
2791
GNG11; G protein subunit gamma 11
55970
GNG12; G protein subunit gamma 12
51764
GNG13; G protein subunit gamma 13
2792
GNGT1; G protein subunit gamma transducin 1
2793
GNGT2; G protein subunit gamma transducin 2
5290
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207
AKT1; AKT serine/threonine kinase 1
208
AKT2; AKT serine/threonine kinase 2
10000
AKT3; AKT serine/threonine kinase 3
1147
CHUK; conserved helix-loop-helix ubiquitous kinase
3551
IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517
IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792
NFKBIA; NFKB inhibitor alpha
4790
NFKB1; nuclear factor kappa B subunit 1
5970
RELA; RELA proto-oncogene, NF-kB subunit
Metabolite
C05981
Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:
23771498
Authors
Bose S, Cho J
Title
Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases.
Journal
Arch Pharm Res 36:1039-50 (2013)
DOI:
10.1007/s12272-013-0161-z
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