KEGG   NETWORK: N00402
Entry
N00402                      Network                                
Name
HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway
Definition
US28 -> GNAQ
  Expanded
K22781 -> 2776
Class
nt06533 Chemokine signaling
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
2776  GNAQ; G protein subunit alpha q
Perturbant
K22781 (US28)  US28; HCMV envelope protein US28
Reference
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
  Authors
Zhang J, He S, Wang Y, Brulois K, Lan K, Jung JU, Feng P
  Title
Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase.
  Journal
PLoS Pathog 11:e1004768 (2015)
DOI:10.1371/journal.ppat.1004768
Reference
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
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