KEGG   NETWORK: N00406
Entry
N00406                      Network                                
Name
HCMV US28 to GNA12/13-Rho signaling pathway
Definition
(CCL2/3/4/5,CX3CL1) -> US28 -> GNA12/13
  Expanded
(6347,6348,6351,6352,6376) -> K22781 -> (2768,10672)
Class
nt06533 Chemokine signaling
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
6347  CCL2; C-C motif chemokine ligand 2
6348  CCL3; C-C motif chemokine ligand 3
6351  CCL4; C-C motif chemokine ligand 4
6352  CCL5; C-C motif chemokine ligand 5
6376  CX3CL1; C-X3-C motif chemokine ligand 1
2768  GNA12; G protein subunit alpha 12
10672  GNA13; G protein subunit alpha 13
Perturbant
K22781 (US28)  US28; HCMV envelope protein US28
Reference
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935
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