NETWORK: N00408
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Entry
N00408 Network
Name
LPAR-GNB/G-Rho signaling pathway
Definition
LPA -> LPAR -> GNB/G -> RHOA
Expanded
C00681 -> (1902,
9170,
23566,
2846,
57121) -> (2782,
2783,
2784,
59345,
10681,
54331,
2785,
2786,
2787,
2788,
94235,
2790,
2791,
55970,
51764,
2792,
2793) -> 387
Class
nt06167
Human cytomegalovirus (HCMV)
Type
Reference
Gene
1902
LPAR1; lysophosphatidic acid receptor 1
9170
LPAR2; lysophosphatidic acid receptor 2
23566
LPAR3; lysophosphatidic acid receptor 3
2846
LPAR4; lysophosphatidic acid receptor 4
57121
LPAR5; lysophosphatidic acid receptor 5
2782
GNB1; G protein subunit beta 1
2783
GNB2; G protein subunit beta 2
2784
GNB3; G protein subunit beta 3
59345
GNB4; G protein subunit beta 4
10681
GNB5; G protein subunit beta 5
54331
GNG2; G protein subunit gamma 2
2785
GNG3; G protein subunit gamma 3
2786
GNG4; G protein subunit gamma 4
2787
GNG5; G protein subunit gamma 5
2788
GNG7; G protein subunit gamma 7
94235
GNG8; G protein subunit gamma 8
2790
GNG10; G protein subunit gamma 10
2791
GNG11; G protein subunit gamma 11
55970
GNG12; G protein subunit gamma 12
51764
GNG13; G protein subunit gamma 13
2792
GNGT1; G protein subunit gamma transducin 1
2793
GNGT2; G protein subunit gamma transducin 2
387
RHOA; ras homolog family member A
Metabolite
C00681
1-Acyl-sn-glycerol 3-phosphate
Reference
PMID:
14512443
Authors
Niu J, Profirovic J, Pan H, Vaiskunaite R, Voyno-Yasenetskaya T
Title
G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.
Journal
Circ Res 93:848-56 (2003)
DOI:
10.1161/01.RES.0000097607.14733.0C
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