KEGG   NETWORK: N00409
Entry
N00409                      Network                                
Name
HCMV UL33 to GNB/G-Rho signaling pathway
Definition
UL33 -> GNB/G
  Expanded
K22782 -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793)
Class
nt06533 Chemokine signaling
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
Perturbant
K22782 (UL33)  UL33; Cytomegalovirus G-protein coupled receptor UL33
Reference
  Authors
Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ
  Title
Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.
  Journal
J Biol Chem 278:50010-23 (2003)
DOI:10.1074/jbc.M306530200
Reference
  Authors
Yamauchi J, Tsujimoto G, Kaziro Y, Itoh H
  Title
Parallel regulation of mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 in Gq-signaling cascade.
  Journal
J Biol Chem 276:23362-72 (2001)
DOI:10.1074/jbc.M011752200
Reference
  Authors
De Cesare D, Fimia GM, Sassone-Corsi P
  Title
Signaling routes to CREM and CREB: plasticity in transcriptional activation.
  Journal
Trends Biochem Sci 24:281-5 (1999)
DOI:10.1016/S0968-0004(99)01414-0
Reference
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
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