KEGG   NETWORK: N00491
Entry
N00491                      Network                                
Name
HTLV-1 p12 to Jak-STAT signaling pathway
Definition
P12 -> IL2RB/G -> JAK1/3 -> STAT5 => IL2
  Expanded
K23069 -> (3560,3561) -> (3716,3718) -> (6776,6777) => 3558
Class
nt06518 JAK-STAT signaling
nt06219 JAK-STAT signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
hsa04061  Viral protein interaction with cytokine and cytokine receptor
Disease
H00009  Adult T-cell leukemia
Gene
3560  IL2RB; interleukin 2 receptor subunit beta
3561  IL2RG; interleukin 2 receptor subunit gamma
3716  JAK1; Janus kinase 1
3718  JAK3; Janus kinase 3
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
3558  IL2; interleukin 2
Perturbant
K23069 (P12)  p12I; HTLV-1 accessory protein p12I
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:11468184
  Authors
Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
  Title
HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
  Journal
Blood 98:823-9 (2001)
DOI:10.1182/blood.v98.3.823
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
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