KEGG   NETWORK: N00507
Entry
N00507                      Network                                
Name
HTLV-1 Tax to TGF-beta signaling pathway
Definition
TAX -| (SMAD2,SMAD3)
  Expanded
K21857 -| (4087,4088)
Class
nt06507 TGFB signaling
nt06218 TGFB signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
4087  SMAD2; SMAD family member 2
4088  SMAD3; SMAD family member 3
Perturbant
K21857 (TAX)  tax; HTLV protein Tax-1
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
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