NETWORK: N00534
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Entry
N00534 Network
Name
HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
X -> BAX
Expanded
K21854 -> 581
Class
nt06524
Apoptosis
nt06263
Hepatocellular carcinoma
nt06162
Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161
Hepatitis B
Disease
H00048
Hepatocellular carcinoma
Gene
581
BAX; BCL2 associated X, apoptosis regulator
Perturbant
K21854
(X)
X; HBV protein X
Reference
PMID:
18481805
Authors
Kim HJ, Kim SY, Kim J, Lee H, Choi M, Kim JK, Ahn JK
Title
Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria.
Journal
IUBMB Life 60:473-80 (2008)
DOI:
10.1002/iub.68
Reference
PMID:
27840960
Authors
Gao WY, Li D, Cai DE, Huang XY, Zheng BY, Huang YH, Chen ZX, Wang XZ
Title
Hepatitis B virus X protein sensitizes HL-7702 cells to oxidative stress-induced apoptosis through modulation of the mitochondrial permeability transition pore.
Journal
Oncol Rep 37:48-56 (2017)
DOI:
10.3892/or.2016.5225
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